알츠하이머병과 관련되어 있는 presenilin 단백질에 의한 세포내 칼슘대사 변화와 기전
알츠하이머병과 관련되어 있는 세포 신호 기전을 바탕으로 치료제 개발
학력
(Ph.D.) Dept. of Biochemistry, Brandeis University (1991)
약력/경력
(Post Doctor) Dept. of Pharmacology, Yale Medical School (1991-1994)
(선임연구원) 아산생명과학연구소 (1994-1996)
(조교수) 중앙대학교 의과대학 (1996-1999)
성균관대학교 의과대학 (1999-현재)
학술지 논문
(2020)
Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains.
MOLECULES.
25,
23
(2020)
High-Cholesterol Diet Decreases the Level of Phosphatidylinositol 4,5-Bisphosphate by Enhancing the Expression of Phospholipase C (PLC beta 1) in Rat Brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
21,
3
(2020)
Substrate-Specific Activation of alpha-Secretase by 7-Deoxy-Trans-Dihydronarciclasine Increases Non-Amyloidogenic Processing of beta-Amyloid Protein Precursor.
MOLECULES.
25,
3
(2019)
O-GlcNAcylation of Amyloid-beta Protein Precursor by Insulin Signaling Reduces Amyloid-beta Production.
JOURNAL OF ALZHEIMERS DISEASE.
69,
4
(2019)
Elevated cellular cholesterol in Familial Alzheimer's presenilin 1 mutation is associated with lipid raft localization of beta-amyloid precursor protein.
PLOS ONE.
14,
1
(2018)
7-Deoxy-trans-dihydronarciclasine Reduces -Amyloid and Ameliorates Memory Impairment in a Transgenic Model of Alzheimer's Disease.
MOLECULAR NEUROBIOLOGY.
55,
12
(2018)
Justicidin A Reduces β-Amyloid via Inhibiting Endocytosis of
β-Amyloid Precursor Protein.
BIOMOLECULES & THERAPEUTICS.
112,
1
(2017)
Activation of transient receptor potential melastatin 7 (TRPM7) channel increases basal autophagy and reduces amyloid beta-peptide.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
493,
1
(2017)
Polychlorinated biphenyl 19 blocks the most common form of store-operated Ca2+ entry through Orai.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.
390,
12
(2017)
O-GlcNAcylation of amyloid-beta precursor protein at threonine 576 residue regulates trafficking and processing.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
490,
2
(2017)
Protective Roles of Monsonia angustifolia and Its Active Compounds in Experimental Models of Alzheimer's Disease.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.
65,
15
(2016)
Bioactive Compound Screen for Pharmacological Enhancers of Apolipoprotein E in Primary Human Astrocytes.
Cell Chemical Biology.
23,
12
(2016)
Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6.
CELL DEATH & DISEASE.
7,
1
(2016)
Stress hormone potentiates Zn2+-induced neurotoxicity via TRPM7 channel in dopaminergic neuron.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
470,
2
(2015)
Threonine 576 residue of amyloid-b precursor protein regulates its trafficking and processing.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
467,
4
(2015)
Coexistence of glutamatergic spine synapses and shaft synapses in substantia nigra dopamine neurons.
SCIENTIFIC REPORTS.
5,
1
(2015)
O-GlcNAcylation Promotes Non-Amyloidogenic Processing of Amyloid-beta Protein Precursor via Inhibition of Endocytosis from the Plasma Membrane.
JOURNAL OF ALZHEIMERS DISEASE.
44,
1
(2015)
Effect of Lycoris chejuensis and Its Active Components on Experimental Models of Alzheimer's Disease.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.
63,
31
(2015)
Regulation of basal autophagy by transient receptor potential melastatin 7 (TRPM7) channel.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
463,
1-2
몬소니아속 식물 추출물을 함유하는 치매 예방 또는 치료용 조성물(Composition for preventing or treating dementia comprising extracts of Monsonia sp.).
10-1360143-0000.
20140203.
대한민국
Composition comprising extracts from Lycoris chejuensis or the
compounds isolated therefrom for preventing and treating dementia.
2009-244257.
20130726.
일본
제주도 석산 추출물 및／또는 지금부터 분리된 화합물을 포함한 퇴행성 신경질환의 예방 및／또는 치료용 조성물.
21244257 .
20130726.
일본
용안육 추출물 또는 이를 포함하는 혼합 추출물을 함유하는 퇴행성 뇌신경질환의 예방 또는 치료용 조성물(Composition comprising longan arillus extract or mixed extracts comprising the same for neurodegenerative diseases).
10-1189191-0000.
20121002.
대한민국
용안육 추출물 또는 이를 포함하는 혼합 추출물을 함유하는 퇴행성 뇌신경질환의 예방 또는 치료용 조성물(Composition comprising longan arillus extract or mixed extracts comprising the same for neurodegenerative diseases).
10-1189191-0000.
20121002.
대한민국
디히드로라이코리시딘을 함유하는 퇴행성 신경 질환의 예방 및/또는 치료용 조성물(Composition for preventing and/or treating a neurodegenerative disease containing dehydrolycoricidine).
10-1163658-0000.
20120702.
대한민국
디히드로라이코리시딘을 함유하는 퇴행성 신경 질환의 예방 및/또는 치료용 조성물(Composition for preventing and/or treating a neurodegenerative disease containing dehydrolycoricidine).
10-1163658-0000.
20120702.
대한민국
Compounds for treating alzheimer's disease and for inhibiting beta-amyloid peptitde production.
20050245465.
20120425.
미국
진세노사이드를 함유하는 마그네슘-뉴클레오타드-작동성 금속이온통로 또는 세포내 칼슘고갈에 의해 작동되는 칼슘통로 활성화 건강기능식품 조성물.
1020100085943.
20120425.
대한민국
진세노사이드를 함유하는 마그네슘-뉴클레오티드-작동성 금속 이온통로 또는 세포내 칼슘고갈에 의해 작동되는 칼슘통로 활성화 건강기능식품 조성물(Health functional food composition comprising ginsenoside compound stimulating magnesium-nucleotide-regulated metal ion channel or capacitative calcium entry).
10-1141971-0000.
20120425.
대한민국
용안육 추출물 또는 이를 포함하는 혼합 추출물을 함유하는 퇴행성 뇌신경질환의 예방 또는 치료용 조성물(Composition comprising longan arillus extract or mixed extracts comprising the same for neurodegenerative diseases).
10-1189191-0000.
20120215.
대한민국
제주상사화 추출물을 함유하는 퇴행성 신경 질환의 예방 및/또는 치료용 조성물(Composition for preventing and/or treating a neurodegenerative disease containing an extract of Lycoris chejuensis and/or a compound isolated therefrom).
10-1119220-0000.
20120215.
대한민국
치매의 예방 또는 치료용 조성물.
10-1093778-0000.
20111207.
대한민국
수상/공훈
Society for Neuroscience, Korean Physiology Society
학술회의논문
(2017)
Elevated cholesterol in a familial Alzheimer’s disease-associated presenilin mutant increases the localization of amyloid precursor protein in lipid rafts.
Society for Neuroscience.
미국
(2017)
Insulin increases O-GlcNAcylation of amyloid precursor protein promoting its non-amyloidogenic processing.
Society for Neuroscience.
미국
(2017)
Activation of TRPM7 channel increases basal autophagy and reduces b-amyloid peptide.
Korean Journal of Physiology and Pharmacology.
대한민국
(2017)
Familial Alzheimer’s disease presenilin 1 mutation elevate cellular cholesterol levels and facilitates lipid raft localization of beta-amyloid precursor protein.
Korean Journal of Physiology and Pharmacology.
대한민국
(2017)
Insulin increases O-GlcNAcylation of amyloid precursor protein promoting its non-amyloidogenic processing.
Korean Journal of Physiology and Pharmacology.
대한민국
(2016)
Justicidin A decreases b-amyloid peptide via inhibiting endocytosis of b-amyloid precursor protein.
Society for Neuroscience.
미국
(2016)
Impaired cholesterol homeostasis contributes to the increased secretion of β-amyloid peptide in Familial Alzheimer’s disease-associated presenilin mutant.
Society for Neuroscience.
미국
(2016)
Insulin promotes non-amyloidogenic processing of amyloid precursor protein through PI3K/Akt signaling..
Society for Neuroscience.
미국
(2015)
Impaired cholesterol homeostasis increases the secreted beta-amyloid peptide in familial Alzheimer's disease-associated presenilin mutant.
67th Korean Physiological Society.
대한민국
(2015)
NDL-PCBs inhibit store-operated Ca2+ entry.
67th Korean Physiological Society.
대한민국
(2015)
Regulation of autophagt and Ab clearaance by TRPM7.
67th Korean Physiological Society.
대한민국
(2015)
O-GlcNAylation of amyloid-b precursor protein at T576 regulates trafficking and processing.
S2015 Society for Neuroscience.
미국
(2014)
Impaired cholesterol homeostasis increases the secretion of -amyloid peptide in Familial Alzheimer’s disease-associated presenilin mutant.
2014 Society for Neuroscience.
미국
(2014)
O-GlcNAcylation of beta-amyloid precursor protein by Justicidin A reduces beta-amyloid peptide.
2014 Society for Neuroscience.
미국
(2014)
Down-regulation of basal autophagy in familial Alzheimer
disease-associated presenilin mutants via decreased TRPM7 channel activity.
2104 Society for Neuroscience.
미국
(2014)
Justicidin A reduces b-amyloid peptide by O-GlcNAcylation of b-amyloid precursor protein.
62th International Congree of the Society for Medicinal Plant and Natural product Research.
포르투갈
(2014)
Crosstalk between cholesterol and PIP2 for the production of b-amyloid peptide.
2014 한국생물물리학회.
대한민국
(2014)
Familial Alzheimer disease-associated presenilin regulates basal autophagy via TRPM7 channel.
2014 한국생물물리학회.
대한민국
(2014)
Regulation of b-amyloid precursor protein endocytosis by O-GlcNAcylation.
2104 한국생물물리학회.
대한민국
(2014)
Impaired cholesterol homeostasis in Familial Alzheimer’s disease-associated presenilin mutant increases the secretion of b-amyloid peptide.
2014 East Asia Joint Symposium on Biomedical Research.
대한민국
